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Bhushan. Borotikar
Télécom Bretagne

M. Bhushan BOROTIKAR

COORDONNEES

LaTIM

  • LaTIM
  • Bâtiment 2bis (I3S)
    CHU Morvan - 5, Av. Foch
  • 29609 Brest CEDEX

Télécom Bretagne

  • Télécom Bretagne
  • Technopôle Brest-Iroise
    CS 83818
  • 29238 Brest Cedex 3



Publications

THESIS TITLE:  “SUBJECT SPECIFIC COMPUTATIONAL MODELS OF THE KNEE TO PREDICT ACL INJURY”

 

by ››

Bhushan BOROTIKAR

dirigee par ››

Antonie J. van den Bogert

title ››

SUBJECT SPECIFIC COMPUTATIONAL MODELS OF THE KNEE TO PREDICT ACL INJURY

these de ››

ENGINEERING SCIENCE

institution ››

Cleveland State University and Cleveland Clinic, Ohio, USA

ecole doctorale ››

Fenn College of Engineering, Cleveland State University, Cleveland, Ohio, USA

date debut ››

2004-08-01

soutenue le ››

2009-12-31

keywords ››

Knee joint modeling, Sports Injury, Injury biomechanics, ACL injury simulation, large scale optimization, cadaveric joint experiments on robot

resume ››

Knee joint is a complex joint involving multiple interactions between cartilage, bone, muscles, ligaments, tendons and neural control. Anterior Cruciate Ligament (ACL) is one ligament in the knee joint that frequently gets injured during various sports or recreational activities. ACL injuries are common in college level and professional athletes especially in females and the injury rate is growing in epidemic proportions despite significant increase in the research focusing on neuromuscular and proprioceptive training programs. Most ACL injuries lead to surgical reconstruction followed by a lengthy rehabilitation program impacting the health and performance of the athlete. Furthermore, the athlete is still at the risk of early onset of osteoarthritis. Regardless of the gender disparity in the ACL injury rates, a clear understanding of the underlying injury mechanisms is required in order to reduce the incidence of these injuries.Computational modeling is a resourceful and cost effective tool to investigate the biomechanics of the knee. The aim of this study was twofold. The first aim was to develop subject specific computational models of the knee joint and the second aim to gain an improved understanding of the ACL injury mechanisms using the subject specific models. We used a quasi-static, multi-body modeling approach and developed MRI based tibio-femoral computational knee joint models. Experimental joint laxity and combined loading data was obtained using five cadaveric knee specimens and a state-of-the-art robotic system. Ligament zero strain lengths and insertion points were optimized using joint laxity data. Combined loading and ACL strain data were used for model validations. ACL injury simulations were performed using factorial design approach comprising of multiple factors and levels to replicate a large and rich set of loading states. This thesis is an extensive work covering all the details of the ACL injury project explained above and highlighting the importance of 1) computational modeling in injury biomechanics, 2) incorporating subject specificity in the models, and 3) validating the models to establish credibility. Techniques used in this study can be employed in developing subject specific injury prevention strategies. These models can be further used to identify gender specific risk factors associated with the ACL injury.

 

COORDONNEES

COURRIEL: Bhushan.borotikar@imt-atlantique.fr

SITE-WEB:

LaTIM

CHU Morvan, Building 1, 
1st floor, Office 1060, 2 Avenue Foch, 
29609 Brest, France 
Phone 02 98 01 81 05 / Fax: 02 98 01 81 24 

 

CV COURT

Understanding musculoskeletal disorders: A Journey through imaging, statistical shape and computational modeling, computer aided surgeries, and medical device designs

Most of my research interests are focused on human movement and musculoskeletal disorders that arise due to various causes. Musculoskeletal disorders are the conditions, diseases, and injuries relating to bones, joints, and muscles. These causes can be work related injuries (anterior knee pain) or sports injuries (anterior cruciate ligament injuries) or as an effect of neurological diseases (Cerebral Palsy) or neurodegenerative disorders (Parkinson’s disease) or non-communicable diseases (diabetes) or degenerative joint diseases (Osteoarthritis, Osteoporosis) etc. I have been working on all the disorders mentioned in the examples above on different levels based on the current understanding of the disorder and lack of knowledge to perform surgeries or rehabilitation in the scientific, clinical, and surgical community.

Depending on the disorder and type of population (adult or children), I work on creating strategies to either optimize the current methods for better surgical outcomes or to find novel solutions that can be clinically validated and implemented. For example, I have been using statistical shape modeling (SSM) approach to understand obstetrician’s branchial plexus palsy in children and how it leads to shoulder deformity as these children grow. Or, in another example, I am focused on developing novel dynamic MRI techniques to understand in vivo ankle joint function in children with equinus deformity due to cerebral palsy. In yet another example, we are developing 3D bone mineral density prediction tools using 2D X-ray image based DRRs (digitally rendered radiographs) and SSM tools for reducing the medical costs and x-ray exposures to patients in developing countries such as India and South Africa. I have been working on sports related injuries like anterior cruciate ligament ruptures and have been devising techniques to either prevent such injuries or to optimize the rehabilitation regimes after surgical reconstruction of such injuries. I have also been developing medical devices such as smart diabetic shoe for patients with neuropathies to predict the onset of ulcers. I have been engaged with Indian universities, research labs, and hospitals for providing guidance on research strategies and methods to the faculties and students as well as to do collaborative research work using the Indo-French research development funds.

Thus, to resolve different clinical and surgical problems that are faced in different musculoskeletal disorders, I use my engineering knowledge to develop tools and procedures using various state-of-the-art techniques. So my research uses various engineering techniques and domains including finite element modeling, dynamic multibody modeling, multiscale modeling, statistical shape modeling, medical image processing, digital signal processing, robotic arms and platform development, bioinstrumentation, biomechanics, medical device designs, gait analysis using motion analysis laboratories etc.

 

Publications

2017

Bhushan Borotikar, Tinashe Mutsvangwa, Valérie Burdin, Enjie Ghorbel, Mathieu Lempereur, Sylvain Brochard, Eric Stindel, Christian Roux. Statistical Shape Modeling for Augmented Orthopaedic Surgery and Rehabilitation. To be published in the book: Medical Image Analysis and Informatics: Computer-aided Diagnosis and Therapy, Edited by Paulo Mazzoncini de Azevedo Marques, Arianna Mencattini, Marcello Salmeri, Rangaraj M. Rangayyan.

2016

Matthias Thépaut, Sylvain Brochard, Julien Leboucher, Mathieu Lempereur, Eric Stindel, Valentin Tissot, Bhushan S. Borotikar. Measuring physiological and pathological femoral anteversion using a biplanar low-dose X-ray system: Validity, reliability and discriminative ability in cerebral palsy. Skeletal Radiology. 2016, 45(2): 243-50.

Salhi A, Mutsvangwa, T, Chimhundu C, Borotikar B, Burdin V. A comparison of two model fitting methods for transferring mesh correspondences: Implications to scapular bone using statistical shape modelling.  54th National Congress of the South African Association of Physicists in Medicine and Biology (SAAPMB), 2016

 

2015

Borotikar B, Ghorbel E, Lempereur M, Mutsvangwa T, Burdin V. Evaluation of an anatomically augmented Statistical Shape Model of the scapula: Clinical validation and reliability of landmark selection. Computer Methods in Biomechanics and Biomedical Engineering, Montreal, Canada, 2015

Ghorbel E, Borotikar B, Mutsvangwa T, Lempereur M, Burdin V. Validation of a new statistical model scapula augmented with anatomical landmarks. Traitement et Analyse de l’Information Methodes et Application (TAIMA), Hammamet, Tunisia, 2015

2014

Otto P, Gavelli F, Borotikar B, Im H, Sikdar S. Quantitative ultrasonic tracking of muscle kinematics using tracklet-based stitching. 39th International symposium on Ultrasonic Imaging and Tissue Characterization Symposium, Arlington, Virginia, 2014

Mutsvangwa TE, Burdin V, Borotikar BS, Roux C. An automated statistical shape model developmental pipeline: Implications to shoulder surgery parameters. Shape Symposium on Statistical Shape Models, Delemont, Switzerland, 2014

2013

Borotikar BS and Sheehan FT. In Vivo Patellofemoral Contact Mechanics During Active Extension Acquired Using a Novel Dynamic MRI-based Methodology. Osteoarthritis and Cartilage, 2013, 21(12):1886-94.

Borotikar BS and Sheehan FT. Functional normative patellofemoral contact mechanics differ between concentric and eccentric muscle activations: A novel in vivo dynamic MRI study. XXIVth Congress of the International Society of Biomechanics, Natal, Brazil, 2013

Sheehan FT, Ma, VY, Alter KE, Borotikar BS. Alteration to in-vivo knee joint contact mechanics following the temporary loss of the vastus medialis strength: implications for patellofemoral pain. XXIVth Congress of the International Society of Biomechanics, Natal, Brazil, 2013

Brochard SB, Borotikar BS, Mozingo JD, Alter KE, Sheehan FT. Three dimensional gleno-humeral deformities in obstetric branchial plexux palsy. XXIVth Congress of the International Society of Biomechanics, Natal, Brazil, 2013

2012

Borotikar BS, Sipprell WH 3rd, Wible EE, Sheehan FT. A methodology to accurately quantify patellofemoral contact kinematics by combining 3D image shape registration and cine-PC MRI velocity data. Journal of Biomechanics, 2012, 45(6): 1117-22.

Borotikar BS, Siddiqui AA, Sheehan FT. The influence of concentric vs. eccentric muscle control on 3D and dynamic patellofemoral contact kinematics. 36th Annual meeting of the American Society of Biomechanics, Gainesville, FL, 2012.

Sheehan FT, Behnam AJ, Borotikar BS, Alter KE. A Vasti medialis nerve block alters in vivo knee joint kinematics: Implications for patellofemoral pain syndrome. Annual Meeting of the Orthopedic Research Society, San Francisco, CA, 2012.

2011

Sheehan FT, Borotikar BS, Behnam AJ, Alter KE. Alterations in in vivo knee joint kinematics following a femoral nerve branch block of the vastus medialis: Implications for patellofemoral pain syndrome. Clinical Biomechanics (Bristol, Avon). 2012, 27(6): 525-31. Recipient of International Society of Biomechanics’ Clinical Biomechanics Award, 2011.

Sheehan FT, Behnam AJ, Borotikar BS, Alter KE. Loss of vasti medialis function alters in vivo knee joint kinematics: Implications for patellofemoral pain syndrome. Recipient of American Society of Biomechanics Clinical Biomechanics award 2011 at the 35th Annual Meeting of the American Society of Biomechanics, Long Beach, CA, 2011.

Wible EE, Sipprell WH, Borotikar BS, Sheehan FT. Accuracy of patellofemoral kinematics using multi-plane 3D shape registration as a precursor to patellofemoral joint contact mechanics. XXIIIrd International Society of Biomechanics Congress, Brussels, Belgium, 2011.

Sheehan FT, Borotikar BS, Behnam AJ, Alter KE. Vasti medialis nerve blocks alter in vivo knee joint kinematics in females: Implications for patellofemoral pain syndrome. Recipient of Clinical Biomechanics award at the XXIIIrd International Society of Biomechanics Congress, Brussels, Belgium, 2011.

 

2010

McLean SG, Borotikar B, Lucey SM. Lower limb muscle pre-motor time measures during a choice reaction task associate with knee abduction loads during dynamic single leg landings. Clinical Biomechanics (Bristol, Avon). 2010, 25(6): 563-9. Times Cited: 5 (from Web of Science).

Sibole S, Bennetts C, Borotikar B, Maas S, van den Bogert AJ, Weiss J, Erdemir A. Open knee: a 3d finite element representation of the knee joint. 34th Annual Meeting of the American Society of Biomechanics, Providence, RI, 2010.

Sipprell WH, Borotikar BS, Sheehan FT. Combining registration with cine-pc data in order to create accurately animated subject-specific knee joint models. Podium presentation at 34th Annual Meeting of the American Society of Biomechanics, Providence, RI, 2010.

Pantano KJ, Wu Y, Borotikar BS. The Influence of an External versus Internal Focus of Attention with regard to Motor Learning and Skill Acquisition for ACL Injury Prevention. Research Retreat V – ACL injuries: The Gender Bias, Greensboro, NC, 2010.

2009

Borotikar BS, Subject specific computational models of the knee to predict anterior cruciate ligament Injury. PhD Dissertation, Cleveland State University, Cleveland, OH. Fall 2009.

Borotikar BS, van den Bogert AJ. A Large scale optimization approach to generate subject-specific knee joint models. Podium presentation at the 33rd Annual Meeting of the American Society of Biomechanics, State College, PA, 2009.

2008

Borotikar BS, Newcomer R., Koppes R., McLean SG. Combined effects of fatigue and decision making on female lower limb landing postures: Central and peripheral contributions to ACL injury risk. Clinical Biomechanics (Bristol, Avon). 2008, 23(1):81-92. Times Cited: 30 (from Web of Science).

Borotikar BS, van den Bogert AJ. Validation of the computational knee joint model under high compressive loading condition. Podium Presentation at the North American Congress on Biomechanics, Ann Arbor, MI, 2008.

Borotikar BS, van den Bogert AJ. Subject Specific Computational Modeling to Predict the Effect of Anatomy on ACL Loading. Podium Presentation at the Research Retreat IV – ACL Injuries: The Gender Bias, Greensboro, NC, 2008.

2007

Borotikar B, Newcomer R, Koppes R, McLean SG. Combined effects of fatigue and anticipation on landing mechanics: Central and peripheral contributions to ACL injury risk. Proceedings of the XXI International Society of Biomechanics Congress, Taipei, Taiwan, 2007.

Borotikar BS, van den Bogert AJ. Knee joint modeling to elucidate ACL injury mechanisms. Podium presentation at the Basic Science Day, Cleveland Clinic, Cleveland, OH, 2007.

 

McLean SG, Koppes R, Huang X, Newcomer R, Borotikar BS. Combined Effects of Fatigue and Decision Making on Landing Mechanics: Understanding Central and Peripheral Contributions to Injury Risk. 54th Annual Meeting of American College of Sports Medicine, New Orleans, LA, 2007.

2006

Borotikar BS, Blankevoort L, McLean SG, van den Bogert AJ. Development of a three-dimensional knee joint model for simulation of ACL injuries. Podium presentation at the 30th Annual Meeting of the American Society of Biomechanics, Blacksburg, VA, 2006.

Goldberg L, McLean SG, Borotikar BS, Calabrese G, Joy S. Effects of  fatigue and decision-making on lower limb movements and loads during high-risk sport postures. 16th Annual Research Day, Dept. of Orthopedic Surgery, Cleveland Clinic, Cleveland, OH, 2006.

2005

Chuong CJ, Borotikar B, Schwartz-Dabney C, Sinn DP. Mechanical characteristics of the mandible after bilateral sagittal split ramus osteotomy: comparing 2 different fixation techniques. Journal of Oral Maxillofac Surgery, 2005, 63(1):68-76. Times Cited: 20 (from Web of Science).

2003

Chuong CJ, Borotikar B, Schwartz-Dabney C, Sinn DP. Comparing 2 fixation techniques for bilateral sagittal split ramus osteotomy. 85th Annual Meeting of the American Association of the Oral and Maxillofacial Surgeons, Orlando, FL, 2003.

Schwartz-Dabney C, Chuong CJ, Borotikar B, Sinn DP. Effect of plating system deployment layouts on maxillary stresses after a simulated Le Fort I procedure. 84th Annual Meeting of the American Association of the Oral and Maxillofacial Surgeons, Chicago, IL, 2002.