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AUTEURS ››Bouzid D, Bert J, Dupré Pierre-François, Bert J, Pradier O, Visvikis D
Title ››Dosimetric validation of an Intrabeam™ GATE model, based on Monte Carlo GEANT4 toolkit, for IORT applications
DANS ››55th AAPM Annual Meeting & Exhibition 2013
PUBLIE EN ››2013
TYPE PUBLI ››Conférence
LANGUE ››GB
Keywords ››IORT, dosimetry, monte carlo, GATE
RESUME ››Purpose: Intraoperative RadioTherapy (IORT) with Intrabeam™ is delivered using a miniaturized
radiation device with applicators generating the prescribed dose directed to the tumor bed. However,
the dose delivered to the patient is not well known. In this context, a Monte Carlo (MC) calculation can
accurately assess the dose delivered to the patient by simulating the particle transport. The aim of this
study is to create and validate an Intrabeam model on the GATE platform, a MC code based on Geant4.
Methods: A model of the Intrabeam™ was created on GATE taking into account dimensions and
materials of each element of the system as well as physical processes. This model was extended to
include simulations based on patient CT images including the presence of applicators within the same
simulation framework allowing their inclusion in the dose calculation. For breast cancer simple
simulations in a water phantom were performed including the bare probe and the spherical applicators,
using soft X-Ray PTW ionization chambers. For spinal metastases, the RANDO phantom was used to
simulate a patient and realistic treatment conditions allowing dose delivery verifications using
thermoluminescent dosimeters (TLD). Finally a breast cancer patient CT acquisition, carried out during
the operation with the applicator in place, was also used in the validation of the Intrabeam™ GATE
model and associated MC based dosimetry using TLDs.
Results: Depth dose curve and isotropy were compared showing a good agreement in water. For breast
application, the comparison between TLD measurements and GATE simulations on patient and
phantom CT images showed a good agreement with less than 1% of deviation (one billion simulated
particles).
Conclusion: The Monte Carlo GATE platform can simulate accurately relative dose distributions
delivered by the Intrabeam system. The proposed model has been validated and will be used for
personalized 3D dose prediction in IORT.

INSERM :
Bouzid D, Bert J, Dupré Pierre-François, Bert J, Pradier O, Visvikis D:Dosimetric validation of an Intrabeam™ GATE model, based on Monte Carlo GEANT4 toolkit, for IORT applications.. 55th AAPM Annual Meeting & Exhibition 2013, 2013,,0-0,C,A,GB.]


BibTex :
@inproceedings{LaTIM-1740
author = {Bouzid D AND Bert J AND Dupré Pierre-François AND Bert J AND Pradier O AND Visvikis D}
title = {Dosimetric validation of an Intrabeam™ GATE model, based on Monte Carlo GEANT4 toolkit, for IORT applications}
booktitle = {55th AAPM Annual Meeting & Exhibition 2013}
year = {2013}
}

Last Updated on Wednesday, 04 February 2009 12:36