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AUTEURS ››Bouzid D, Boussion N, Dupré Pierre-François, Bert J, Pradier O, Visvikis D
Titre ››Personalized 3D dose prediction for Intrabeam™ treatments based on patient CT imaging with Monte Carlo GATE simulations
DANS ››55th AAPM Annual Meeting & Exhibition 2013
PUBLIE EN ››2013
TYPE PUBLI ››Conférence
LANGUE ››GB
Mots clés ››IORT, dosimetry, monte carlo, GATE
RESUME ››Purpose: The aim of partial breast irradiation is to prevent, in a short period and less transportations, the risk of local recurrence into the tumor bed. After surgical resection of the tumor, the Intrabeam system delivers a single dose fraction of 20 Gy at the surface of the applicator for irradiating the tumor bed through an X-ray beam of low energy (50 kV). However, there is no latitude for personalized prescription and this point is questionable since a number of official texts recommend individual dose optimization. In this context, the aim of this study is to perform personalized 3D dose prediction for Intrabeam™ treatments based on patient CT imaging with Monte Carlo GATE simulations.

Methods: A model of the Intrabeam™ system was performed realistically on the GATE Monte Carlo platform taking into account each element of the system. A preoperative CT acquisition of the patient breast is performed and included in the simulation allowing dose calculation. During intra-operative radiotherapy, thermoluminescent dosimeters are placed on the skin at 1 and 3 cm around the spherical applicator. Comparison between simulation results and TLD measurements are performed to confirm the prediction. This study was performed on 10 patients, including 3 who have an intraoperative CT acquisition in order to confirm initial results.

Results: Preliminary results on first patients show encouraging results between clinical experiments and simulations. Indeed the relative mean deviation between TLD dose measurements and GATE dose scoring is 0.09% ± 0.11% with a maximum of 0.334% and less than 1% of GATE uncertainty (min 0.41% max 0.95%).

Conclusion: We propose an accurate model of the Intrabeam system on the GATE platform based on Monte Carlo Geant4 toolkit. The global aim of our work is to evaluate the dosimetric treatment plan given by GATE with clinical treatment delivery, in order to perform adaptive radiotherapy for each patient.

INSERM :
Bouzid D, Boussion N, Dupré Pierre-François, Bert J, Pradier O, Visvikis D:Personalized 3D dose prediction for Intrabeam™ treatments based on patient CT imaging with Monte Carlo GATE simulations.. 55th AAPM Annual Meeting & Exhibition 2013, 2013,,0-0,C,A,GB.]


BibTex :
@inproceedings{LaTIM-1741
author = {Bouzid D AND Boussion N AND Dupré Pierre-François AND Bert J AND Pradier O AND Visvikis D}
title = {Personalized 3D dose prediction for Intrabeam™ treatments based on patient CT imaging with Monte Carlo GATE simulations}
booktitle = {55th AAPM Annual Meeting & Exhibition 2013}
year = {2013}
}

Mise à jour le Mercredi, 04 Février 2009 12:36