• Increase font size
  • Default font size
  • Decrease font size

Publications

E-mail Print PDF
AUTEURS ››Bouzid D, Bert J, Dupré Pierre-François, Benhalouche S, Pradier O, Visvikis D, Boussion N
Title ››Monte Carlo simulation of the INTRABEAM ® system with the platform GATE for breast cancer.
DANS ››DEGRO 2013 – 19th Annual Congress
PUBLIE EN ››2013
TYPE PUBLI ››Conférence
LANGUE ››GB
Keywords ››IORT, dosimetry, monte carlo, GATE
RESUME ››Introduction
This work is in the context of Monte Carlo simulation in intraoperative radiotherapy. It aims to study the modeling of a new device installed at the University Hospital of Brest in 2011 named INTRABEAM ™ on the GATE platform.

Materials et Methods

The system INTRABEAM ™ is mainly for breast cancer treatment for tumors less than or equal to 2 cm in diameter. Spherical applicators with varying diameters depending on the tumor size (2.5 cm to 5 cm) are mounted on the system to have an isotropic distribution of the dose. After resection of the tumor, the surgeon inserts the applicator in place of the tumor and the system delivered a single fraction of 20 Gy to the surface of the applicator for irradiating the tumor bed with a beam of X-rays low-energy (50 kV). There is no requirement customized and this is questionable since an official document recommends a single dose optimization. This study is divided into two stages:
(1) A model of the INTRABEAM™ system was created realistically and simple simulations in a water phantom were performed to validate the model.
(2) In the second part, the model is used to perform dose calculations customized from CT images of the patient, to take into account tissues heterogeneities.
Monte Carlo simulations on the GATE platform are made precisely as the experimental geometry. The depth dose curves for the bare probe and for applicators available are analyzed. The experimental dose measurements were performed with an ionization chamber PTW and thermoluminescent dosimeters. The isotropy of the source has been also verified. The simulation results are compared with experimental measurements.

Results

The user interface of the GATE platform facilitates system modeling INTRABEAM. The simulation results obtained from the model developed shows a good fit with the experimental measurements and those are confirmed with personalized study on CT images.

Conclusion

The Monte Carlo simulation allows a precise evaluation of the dose actually delivered and paves the way for personal dosimetry taking into account tissue heterogeneities. This model can be considered validated and could be used to predict dose 3D treatment planning.

INSERM :
Bouzid D, Bert J, Dupré Pierre-François, Benhalouche S, Pradier O, Visvikis D, Boussion N:Monte Carlo simulation of the INTRABEAM ® system with the platform GATE for breast cancer... DEGRO 2013 – 19th Annual Congress, 2013,,0-0,C,A,GB.]


BibTex :
@inproceedings{LaTIM-1744
author = {Bouzid D AND Bert J AND Dupré Pierre-François AND Benhalouche S AND Pradier O AND Visvikis D AND Boussion N}
title = {Monte Carlo simulation of the INTRABEAM ® system with the platform GATE for breast cancer.}
booktitle = {DEGRO 2013 – 19th Annual Congress}
year = {2013}
}

Last Updated on Wednesday, 04 February 2009 12:36